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40 percent of U.S. children are exposed to a cumulative amount of organo-phosphate pesticides from the food they eat and water they drink at levels that exceed benchmarks for neurological harm. Either a theraputic program to detox our children from previous exposure (1/2 to 1 scoop daily), or a daily preventative dose (1/4 scoop) of our new, most up to date detox formula, Dynamic Detox (formulated by detox expert and educator on detox for the IFM, Dr. Richard Mayfield) would provide the protection our children need and deserve.

Evaluating Cumulative Organophosphorus Pesticide Body Burden of Children: A National Case Study

Devon Payne-Sturges*Jonathan CohenRosemary Castorina§Daniel A. Axelrad and Tracey J. Woodruff

Environ. Sci. Technol., 2009, 43 (20), pp 7924–7930

DOI: 10.1021/es900713s

Publication Date (Web): September 15, 2009

Program on Reproductive Health and the Environment, University of California.                           Cite this:Environ. Sci. Technol. 2009,  43, 20, 7924-7930

Synopsis

Risk interpretation of biomonitoring data indicates that 40% of U.S. children may have had increased risk for neurological impacts from cumulative exposures to OP pesticides in 1999−2002.

Abstract

Biomonitoring is a valuable tool for identifying exposures to chemicals that pose potential harm to human health. However, to date there has been little published on ways to evaluate the relative public health significance of biomonitoring data for different chemicals and even less on cumulative assessment of multiple chemicals. The objectives of our study are to develop a methodology for a health risk interpretation of biomonitoring data and to apply it using NHANES 1999−2002 body burden data for organo-phosphorus (OP) pesticides. OP pesticides present a particularly challenging case given the nonspecificity of many metabolites monitored through NHANES. We back-calculate OP pesticide exposures from urinary metabolite data and compare cumulative dose estimates with available toxicity information for a common mechanism of action (brain cholinesterase inhibition) using data from U.S. EPA. Our results suggest that approximately 40% of children in the United States may have had insufficient margins of exposure (MOEs) for neurological impacts from cumulative exposures to OP pesticides (MOE less than 1000). Limitations include uncertainty related to assumptions about likely precursor pesticide compounds of the urinary metabolites, sources of exposure, and intra-individual and temporal variability.